Increase in rat pup ultrasonic isolation
calls induced by lindane.
S. Rivera, C. Sanfeliu, M. García*, F. Comellas+ and E.
Rodríguez-Farré
Department of Pharmacology and Toxicology, CSIC,
c/Jordi Girona 18-26;
E-08034 Barcelona.
*Electronic Engineering Department, Polytechnic University of Catalonia,
c/Jordi Girona s/n; 08034 Barcelona.
+Applied Mathematics and Telematics Department, Polytechnic University of
Catalonia, c/Jordi Girona s/n; 08034 Barcelona.
Current issues in Neurotoxicology,
A. Mutti, L. Costa, L. Manzo y J.M. Cranmer. (Eds.),
Intox Press, Inc. Publishers,
pp. 235-239, (1992). ISBN 0-911369-16-3
Neurotoxicology, vol. 13 ,
pp. 235-239, (1992).
The neurotoxic agent lindane was tested for its ability to alter the
rate of ultrasonic isolation calls of suckling rats. Doses that did not produce
any sign of convulsant activity significantly increased the number of calls and
the cumulative time of calling in male pups. At days 10-13 of age after a
single dose of 20 mg/kg lindane, animals showed more than twice the control
call values. After daily dosing with 10 mg/kg during the first week of age call
increases also appeared. It is suggested that lindane has an anxiogenic effect
mediated through its action on the benzodiazepine-GABASDO1(A) receptor-chloride
channel complex.
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